BDBM392102 US10301272, Example 8/7
SMILES C[C@H](NC(=O)c1cc(cc(c1)C1(C)CC1)-c1sc(nc1CC1CCCCC1)C(=O)N[C@H]1C[C@@H](C1)C(O)=O)C(F)(F)F
InChI Key InChIKey=PSFPATVFAWGHAJ-BUKVSMQUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 392102
Affinity DataIC50: 1.20nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataKd: 1.5nMAssay Description:Binding affinity to recombinant human RORgamma LBD (237 to 497 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermoflu...More data for this Ligand-Target Pair
Affinity DataEC50: 505nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in IL17A productionMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Inverse agonist activity at RORgammat in human CD4 positive T cells assessed as inhibition of IL17A production in human Th17 cells after 1 hrMore data for this Ligand-Target Pair